European Journal of Molecular & Clinical Medicine

The use of herbal remedies to cure medical issues is extensive. They have been used for generations to cure gingival disease, periodontitis, oral infections, stained teeth, etc. However, there are some research that have gathered data on their impacts. The objective of this review article is to collect and compile data on a few significant herbs that are utilized in dental treatment.

Four new oxadiazole derivatives, 5-(2-chlorophenyl)-1, 3, 4-oxadiazole-2-amine, 5-(3-nitrophenyl)-1, 3, 4-oxadiazole-2-amine, 4-(5-amino-1, 3, 4-oxadiazole-2-yl)phenol, 5-(3,4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2-amine have been synthesized, characterized and studied for in-vitro antimicrobial activities. The antibacterial studies is carried out against bacteria E.coli, Bacillus subtilis, Micrococcus letteus and the anti-fungal studies is carried out against fungus candida albicans, Sacromyces cervesiae at concentrations 50μg/ml, 100 μg/ml and 150μg/ml. The potency of the derivatives is analysed against standard antibiotic drug ampicillin at 100μg/ml. Compounds 5-(2-chlorophenyl)-1, 3, 4-oxadiazole-2-amine and 5-(3,4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2-amine are found more effective than ampicillin, which may be explored as new analogues in antibiotic category.