European Journal of Molecular & Clinical Medicine

Background: A recent increase in the prevalence of overweight and obese women of reproductive age in India has been noted. Obesity during pregnancy is associated with an increased risk of gestational diabetes mellitus (GDM), pre‐eclampsia, miscarriage, venous thromboembolism, infection, and hemorrhage in the mother. The present study was aimed to explore various maternal and fetal outcomes, influenced by maternal obesity. Material and Methods: Present study was hospital based, prospective, observational study conducted in pregnant women, gestational age more than 32 weeks, singleton pregnancy, with BMI more than 30, delivered at our institute, willing to participate in present study. Results: During study period 107 pregnant women were considered for present study. Majority of women were from 26-30 years age (40.19 %), were primigravida (44.86 %), delivered at 37-40 weeks of gestation (40.19 %), 85.05 % had BMI 30-34.9 kg/m2 (moderately obese). In present study vaginal delivery was most common mode of delivery (52.34 %) followed by LSCS (40.19 %) & instrumental delivery (7.48%). Most common birth weight group was 2.5-3.99 kg (40.19 %), followed by 1.5-2.49 kg (34.58 %) group. Neonatal outcome noted was still birth (1.87 %), neonatal death (6.54 %) & rest of neonates were discharged with mother. 63.55 % babies required NICU admission. During postpartum period, complications such as wound infection (19.63 %), fever (14.02 %), wound dehiscence (6.54 %) & DVT (0.93 %) were noted. No maternal mortality was noted in present study. Conclusion: Maternal obesity is associated with development of gestational diabetes mellites, preeclampsia, need for labour induction, increased caesarean delivery as well as NICU admissions and increased incidence of postpartum infections.

Background: Cervical ripening and/or labour induction in women’s have not been proven to be the most effective, safest, or most effective methods. In order to better understand the factors that determine the efficacy of mechanical induction using a Foley’s bulb, this study was conducted on patients who had previously undergone a one lower segment caesarean surgery with an unsalvageable infant (in our current configuration). Aim: To study and compare maternal and fetal outcome after induction of labor with foleys catheter and cervical ripening balloon in cases of previous 1 LSCS. Material & Methods: This was prospective observational study was conducted in the department of obstetrics and gynaecology of rural tertiary health care center, Karad from Dec 2020 – May 2022. Results: Among 63 cases were found <=6 post catheter Bishop Score in cervical ripening balloon (CRB) group whereas 25 (39.7%) in Foleys group. 49 (77.8%) out of 63 cases were found >6 post catheter Bishop Score in CRB group whereas 38 (60.3%) in Foleys group. A p-value is 0.034 calculated using Chi-square test. There was significance difference found in both the study groups. Here 45 (71.4%) out of 63 cases were found vaginal delivery in CRB group whereas 34 (54.0%) in Foleys group. The mode of delivery, 18 (28.6%) out of 63 cases were observed C-section in CRB group whereas 29 (46%) in Foleys group. The P value was 0.0463 calculated by Chi-square test. In CRB group birthweight of neonate is significantly higher compared to foleys group. Conclusion: Bishop Score increment by CRB group is more effective than induction by Foley group.

Aim and Objectives: The aim of the present study was to assess the safety and efficacy of vaginally administered misoprostol 25mg with intravenous oxytocin for labor induction in term prelabour rupture of membranes.
The subjects with rupture of membranes without labor were assigned to receive either vaginally administered misoprostol 25 micrograms or intravenous oxytocin infusion this prospective study was conducted during February 2014 to January 2016 in the Department of Obstetrics and Gynecology of Regional Institute of Medical Sciences, Imphal, India.
Results and Observation: Of the 192 subjects 96 received intravaginal misoprostol and 96 received intravenous oxytocin It was observed that the average interval from start of induction to delivery was about one hour shorter in misoprostol group (12.58+4.08 hours vs 14.00+3.31 hrs) than in oxytocin group (P=0.05). Vaginal delivery occurred in 82 misoprostol treated group and in 80 oxytocin treated group (85.4% vs 83.3%, P= 0.691).Caesarean section was done in 14 of misoprostol treated subjects and in 16 oxytocin treated subjects (14.6% vs 16.7%) which is not statistically significant.
Conclusion: Vaginal administration of misoprostol is an effective alternative to oxytocin infusion for labor induction in women with prelabour rupture of the membranes at term.

Background- The labour induction becomes necessary when the continuing the pregnancy could result in maternal and fetal complications. Cervical ripening is essential for success of normal delivery, so attempts are made to ripen the cervix in a small span of time.
Aim- To study the comparative impact of “Transcervical Foley's Catheter with vaginal misoprostol on labour induction versus vaginal misoprostol alone” at or after 36 weeks of gestation.
Method- A cross- sectional study conducted in the rural area of India involves 120 full term pregnant females selected by systematic random sampling technique and the labour will be induced either by Foley’s catheter along with misoprostol or misoprostol alone.
Result - In females induced with the Foley catheter along with vaginal misoprostol in both
Primigravida and multigravida females, the time from induction to delivery is predicted to be substantially reduced. Conclusion- Due to synergistic effect of intracervical Foley’s catheter and vaginal misoprostol for cervical ripening and induction of labour, the time from induction to delivery interval will be reduced, prolongation of labour will be decreased and unnecessary caesarian section can be avoided.