Online ISSN: 2515-8260

Keywords : misoprostol


A comparative study of oral V/S vaginal misoprostol for induction of labor conducted at Karwar institute of medical science, Karwar, Karnataka

Dr. Shivanand Kudtarkar, Dr. Annappa Shetty, Kishan Kudtakar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 332-336

Objective: To study the efficacy of 50 μg of Misoprostol tablet for induction of labor, oral v/s vaginal
route.
Methods: 100 women, at term gestation, with various indication for induction of labor with Bishop’s
score of ≤4 were included. After deciding, 50 women received 50 μg orally and 50 women received 50
μg vaginally every fourth hourly (maximum of 6 doses) or till they went into active labor.
Results: After statistical analysis it was found that in vaginal misoprostol route the induction to delivery
interval was significantly less compared to oral misoprostol group (9.5 v/s 160).
It was also found that the required dose of drug in vaginal route is less compared to oral route (40% of
women need only 2 doses in vaginal group compared to 35% of oral group were 6 doses required).
Conclusion: For induction of labor vaginal misoprostol is always more effective compared to oral rout

EVALUATION OF EFFICACY AND SAFETY OF MISOPROSTOL FOR CERVICALRIPENINGANDINDUCTIONOFLABOURBYTWODIFFERENTROUTES

Dr. Kavita Chhabra, Dr.Divya Saraswat

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1866-1869

BACKGROUND: Cervical ripening is one of the methods employed for induction of labour.
Cervicalripening involves the usage of pharmacological agents or other means to soften, efface or
dilate thecervix to increase the likelihood of a vaginal delivery. Induction of labour (IOL) is the
process
ofinitiatingcontractionsinpregnantpersonswhoarecurrentlynotinlabour,tohelpthemachievevaginaldel
ivery within 24 to 48 hours. OBJECTIVE OF THE STUDY: The objective of the study is
tocompare the efficacy and safety of two different routes of regimen of misoprostol for cervical
ripeningand induction of labour. MATERIALS &METHODS: This prospective comparative
study, wasconducted in the Department of Obstetrics and Gynaecology at Adesh Medical College,
for a periodfrom may January 2021 to June 2021. We enrolled 100 patients in our study. We
divided the
patientsintotwogroupsrandomlyintoGroupAandGroupB.GroupAweadministeredmisoprostolvaginal
lyandGroupBsublingually.Thedoseusedforboththegroupswas25μg.RESULTS&CONCLUSIONS:
In our study, we found that there were no statistically significant differences indemographis,
Bishops Score after induction, number of doses required, complications (foetal distress,meconium
stained liquor and hyper stimulation), maternal side effects and neonatal Apgar
Scoresbetweenthetwogroups.Therewerestatisticallyhighlysignificantdifferencesintheneedforoxytoci
naugmentation between the two groups. Oxytocin augmentation was more in group B in patients
ascomparedto patients in group A.

Foley’s Catheter And Vaginal Misoprostol Versus Vaginal Misoprostol Alone For Labour Induction

Dr. Shikha Toshniwal; Dr. Saunitra Inamdar; Dr. Himanshi Agarwal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2150-2157

Background- The labour induction becomes necessary when the continuing the pregnancy could result in maternal and fetal complications. Cervical ripening is essential for success of normal delivery, so attempts are made to ripen the cervix in a small span of time.
Aim- To study the comparative impact of “Transcervical Foley's Catheter with vaginal misoprostol on labour induction versus vaginal misoprostol alone” at or after 36 weeks of gestation.
Method- A cross- sectional study conducted in the rural area of India involves 120 full term pregnant females selected by systematic random sampling technique and the labour will be induced either by Foley’s catheter along with misoprostol or misoprostol alone.
Result - In females induced with the Foley catheter along with vaginal misoprostol in both
Primigravida and multigravida females, the time from induction to delivery is predicted to be substantially reduced. Conclusion- Due to synergistic effect of intracervical Foley’s catheter and vaginal misoprostol for cervical ripening and induction of labour, the time from induction to delivery interval will be reduced, prolongation of labour will be decreased and unnecessary caesarian section can be avoided.