Online ISSN: 2515-8260

Keywords : Serum uric acid

A study on association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital

Premaraja R, Bethiun S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2013-2019

Background: Hypertension is an increasing important medical and public health issue. Uric acid exerts a pro-inflammatory effect on endothelial cells which may be associated with MetS risk factors such as elevated triglyceride (TG) levels, hypertension and insulin resistance.5 Present study was aimed to study of association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital.
Material and Methods: Present study was prospective, comparative, observational study, conducted among cases (Subjects of either gender, age >18 years, diagnosed as hypertensive (first time) were enrolled in this study during a regular routine health check-up at general medicine OPDs) & controls (Age & gender matched normotensives subjects at general medicine OPDs).
Results: In present study, 100 subjects each were studied in hypertensive as well as normotensive group. Mean levels of age, gender, BMI & co-morbidities among both groups were comparable & difference was not significant statistically. Mean pulse rate & respiratory rate were comparable among both groups & difference was not significant statistically. The mean levels of SBP and DBP were significantly more in the hypertensive subjects as compared to normotensive subjects (p < 0.001). In present study, prevalence of hyperuricemia was 9% (1% in normotensive and 8% in hypertensive subjects). Hypertensive subjects had increased mean levels of SUA than in the normotensive subjects (p < 0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP (p < 0.001). The average level of TG and HDL were also significantly different between the groups (p < 0.05).
Conclusion: A stronger co-relationship for higher levels of SUA concentration was noted with blood pressure hypertension and prehypertension in the participants.



European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2075-2082

BACKGROUND: A major health problem is hypertension during pregnancy. This complicates In India, around 5 to 10 percent of pregnancies occur. Preeclampsia is a disorder whose pathogenesis is still not clearly understood. One theory suggested that the cause of PE is, endothelial dysfunction is brought about by certain factors released from ischemic placenta leading to poor uterine and placental perfusion. Preliminary executive research suggests that serum LDH and uric acid are abnormal in women with preeclampsia-eclampsia and usual in women with normotension. AIM AND OBJECTIVES: We aim to study the correlation between serum lactate dehydrogenase levels and serum uric acid levels in in normotensive pregnant women and preeclamptic-eclamptic pregnant women together with their feto-maternal performance. The objectives of the study to compare and correlate serum lactate dehydrogenase and serum uric acid levels in normotensive and preeclamptic-eclamptic women with feto-maternal outcome. MATERIALS AND METHODS: This is a prospective observational study and will be conducted in the obstetrics and gynaecology department, AVBRH, DMIMS (Deemed to be University, Wardha), situated in the rural area of Wardha district in over 230 patients for period between 2020-23. This study will include antenatal patients of age 18 - 35yrs, gestation 28-40 weeks, normotensive and preeclampsia-eclampsia women and will exclude mothers with hypertension < 20 weeks of gestation (Chronic Hypertension), multiple pregnancy, pre-existing Diabetes Mellitus, liver disorder, renal disorder, epileptic disorder, thyroid disorder, Heart Disease, leukaemia, haemolysis and hepatitis. EXPECTED RESULTS: We expect that there will be significant difference in maternal and fetal outcome based on serum lactate dehydrogenase and serum uric acid concentration in normotensive and preeclamptic -eclamptic pregnant women.