Online ISSN: 2515-8260

Keywords : Serum LDH


ANALYSIS OF BIOCHEMICAL MARKERS TO PREDICT DISEASE SEVERITY IN HOSPITALIZED COVD-19 PATIENTS, PUNE

Dr Charusheela R Gore, Dr Vinayak Sharma, Dr Sachin Shivnitwar, Dr Archana Buch, Dr Banyameen Iqbal .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 3234-3244

Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), which causes coronavirus disease 2019 (COVID‑19), has swiftly grown into a pandemic. Despite extensive research, the function of numerous haematological and biochemical markers in prognosis remains unknown. There have been scientific papers in the Indian setting that describe demographics, clinical characteristics, hospital course, morbidity, and death in COVID-19 patients, however the numbers are limited. The current study provided us with a better understanding of the disease development and progression in COVID-19 patients, as well as the factors that determine disease severity.
Methods: This study was carried out at a COVID-19 tertiary care facility at Dr. D. Y Patil Medical College, Hospital and Research Centre, Pune. The demographic and clinical information, laboratory parameters of admitted COVID‑19 patients were collected were subsequently analysed.
Results: The mean (SD) age of COVID 19 patients was 48.21(16.37) years. The total number of COVID-19 patients with mild disease was 273 (45.27%), moderate disease was 177 (29.35%), and severe disease was 153 (25.37%). The Serum urea, serum AST, Serum total bilirubin, Serum Conjugated Bilirubin, Serum Unconjugated bilirubin , serum  LDH, Serum CRP and Serum Ferritin were differ significantly between mild, moderate, and severely ill  COVID-19 cases.
Conclusion: In conclusion the study revealed the role of numerous biochemical indicators in the severity of COVID-19, as well as the order of effectiveness among the markers. Our findings suggested that LDH and CRP levels were a promising biomarker for predicting COVID-19 severity.

Study of serum LDH levels and its correlation with maternal and perinatal outcome in preeclampsia

Arati Mane, C.S.Patil(Dawle), Akuskar Roshani

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 12203-12208

Background: Pre-eclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Lactate dehydrogenase (LDH) is an intracellular enzyme which converts pyruvic acid to lactic acid during glycolysis Present study was aimed to study the correlation of maternal and perinatal outcomes with serum LDH levels in women with hypertensive disorders of pregnancy.
Material and Methods: Present study was prospective, observational study, conducted in antenatal women with singleton pregnancy and gestational age 28 weeks onward with hypertensive disorders of pregnancy (mild/ severe pre-eclampsia), serum LDH levels were estimated.
Results: In present study, 50 pregnant women were studied. Majority women were from 20-25 years age group (60 %), nulliparous (70 %), unbooked (68 %). Hypertensive disorders of pregnancy were mild pre-eclampsia (56 %) & severe pre-eclampsia (44 %). In present study, Mean LDH value in mild preeclampsia group was 564.3 ± 184.3 IU/l & in severe preeclampsia group was 766.3 ± 264.3 IU/l, difference was statistically significant. Majority women underwent LSCS (64 %). Maternal complications such as eclampsia, abruption, HELLP were more in > 800 IU/L LDH value patients. Perinatal outcome was poor in pregnant women with > 800 IU/L LDH value, 8 (16 %) neonates required NICU admission, while 7 (14 %) were low birth weight. Perinatal mortality was noted in 2 cases (1 from 600-800 IU/L LDH group & 1 from >800 IU/L LDH group).
Conclusion: With raised LDH values, decision regarding management and prevention of complications should be taken, so as to reduce the maternal & neonatal, morbidity & mortality.

“TO STUDY SERUM LDH AND SERUM URIC ACID LEVELS IN NORMOTENSIVE AND PREECLAMPTIC-ECLAMPTIC PREGNANT WOMEN AND ITS CORRELATION WITH FETO-MATERNAL OUTCOME.”

ELETI MANILA REDDY; MANJUSHA AGRAWAL

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2075-2082

BACKGROUND: A major health problem is hypertension during pregnancy. This complicates In India, around 5 to 10 percent of pregnancies occur. Preeclampsia is a disorder whose pathogenesis is still not clearly understood. One theory suggested that the cause of PE is, endothelial dysfunction is brought about by certain factors released from ischemic placenta leading to poor uterine and placental perfusion. Preliminary executive research suggests that serum LDH and uric acid are abnormal in women with preeclampsia-eclampsia and usual in women with normotension. AIM AND OBJECTIVES: We aim to study the correlation between serum lactate dehydrogenase levels and serum uric acid levels in in normotensive pregnant women and preeclamptic-eclamptic pregnant women together with their feto-maternal performance. The objectives of the study to compare and correlate serum lactate dehydrogenase and serum uric acid levels in normotensive and preeclamptic-eclamptic women with feto-maternal outcome. MATERIALS AND METHODS: This is a prospective observational study and will be conducted in the obstetrics and gynaecology department, AVBRH, DMIMS (Deemed to be University, Wardha), situated in the rural area of Wardha district in over 230 patients for period between 2020-23. This study will include antenatal patients of age 18 - 35yrs, gestation 28-40 weeks, normotensive and preeclampsia-eclampsia women and will exclude mothers with hypertension < 20 weeks of gestation (Chronic Hypertension), multiple pregnancy, pre-existing Diabetes Mellitus, liver disorder, renal disorder, epileptic disorder, thyroid disorder, Heart Disease, leukaemia, haemolysis and hepatitis. EXPECTED RESULTS: We expect that there will be significant difference in maternal and fetal outcome based on serum lactate dehydrogenase and serum uric acid concentration in normotensive and preeclamptic -eclamptic pregnant women.