European Journal of Molecular & Clinical Medicine

The present study was conducted in the Department of medicine,Gandhi Hospital,
Secunderabad. 100 malarial fever cases were taken up for the study, which consisted of
79(79%) males and 21% females. Among this, 55% cases were of p.vivax and 45%
p.falciparum. The maximum number of cases fell in the age group of 15-35 years (62%).
100% cases presented with fever, chills and rigors. Other presenting symptoms were
headache (25%)and vomiting (33%). Splenomegaly was seen in 32% cases, while
hepatomegaly in 22%, 15% showed pallor and 8%cases had icterus. Complete
hematological tests were done on cases taken for study and analyzed. Anemia ranged
from 6.0 to 15.6gm/dl, leukocyte count varied from 1.8 to 17.7cu/mm. Platelet count was
done on every patient on day 1, 2, and 3.Thrombocytopenia was seen in 31% (31) cases
of p.vivax, 24% of p.falciparum patients. Association of thrombocytopenia and effect of
treatment was completely analyzed in both p.falciparum and p.vivax the effect of
antimalarial drugs on platelet count was observed. On Day 1 platelet count varied
from 15,000 to 1,94,000. On Day 2 platelet count varied from 14,000 to 1,84,000. On Day
3 platelet count varied from 26,000 to 1,98,000.

Pigmented lesions of the oral mucosa are encountered on a routine basis in clinical practice. Oral health-care providers must assess several parameters associated with pigmented lesions. Oral mucosal color changes can be significant and gives diagnostic value of local or systemic disease though it requires clinical experience and thorough evaluation. Color changes in the oral mucosa can be attributed to the deposition of either endogenous or exogenous pigments as a result of various mucosal diseases. The various pigmentations can be in the form of blue/purple vascular lesions, brown melanotic lesions, brown heme‑associated lesions, gray/black pigmentations. Therefore, watchful examination of all the oral mucosa is frequently required. There are variable manifestation of oral pigmentation. The specific shade, extent, site, spreading of lesion gives diagnostic importance. Interactions between the dentist and the patient's medical specialist are very important to provide a definitive diagnosis as it increase the possibility to recognize these forms of lesions. Further and more work will be done to clarify the pathogenesis and to improve the diagnosis of the disease. The historical and current scientific history and the comprehensive research on the use of patients' medications have played a vital role. Such pigmentations can be caused by both systemic and topical drugs. Interactions between the dentist and the patient's medical specialist are very important to provide a definitive diagnosis as it increase the possibility to recognize these forms of lesions.