Author : Arvinth . C, Akshay. B.S, Vignesh . D, Manju. D, Ram Vignesh . N, Sowmyasri. D, Bellarmin .M, Deepa. N, Hemamalini . K, Nivedha . M, Avinash . M, Harsha . S, Krishna. S, Kailash. K.A,
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 10607-10610
For treatment, the current system of popular medicine uses a lot of essential oils and their components.Cardamom, Ajowan, Fennel, Caraway, Coriander, and Peppermint have been utilized in Indian medicine for centuries. These are also said to help with gastrointestinal problems, making them a good option for the current study. Steam distillation is a popular method for extracting essential oils from dried seeds or leaves.This study aims to create a microemulsion utilizing a combination of essential oils, water, and the non-toxic, non-ionic surfactant, as well as ethanol as a cosurfactant. The antacid action of the manufactured product was then tested.All the studies were carried out with water collected from a Millipore gradient Water System (Millipore Ltd., Bangalore, India). Analytical grade reagents were employed for the study, including methanol, hydrochloric acid, sodium hydroxide, sodium carbonate, and others. All marker standards were purified to a minimum of 98 per cent purity.Antacid medicine should have a long enough duration of action to keep the pH of the stomach above 3. The product's 10 mL and 20 mL doses showed in vitro similar antacid characteristics and considerable acid reactivity.As a result, several plants with a penchant for neutralizing stomach acid are chosen, and a formulation is created. Oil microemulsions with 110-410nm droplet sizes showed more excellent stability. After that, the compound was tested in vitro for antacid characteristics, which revealed a substantial positive response.