Author : Abdelal, Amany Abo Elsoud, Nahla I. Elattar, Dina A. Abd Elhafeezc, Ibrahim T.
Predictive Value Of 14-3-3 Eta Protein as A Novel Biomarker in Juvenile Idiopathic Arthritis (Oligoarticular Type): Relation to Activity and Severity of The Disease
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 4543-4551
Background: Juvenile idiopathic arthritis (JIA) is a term that encompasses all forms of
arthritis that begin before a patient is aged 16 years that persist for more than 6 weeks and
are of unknown origin. It is the most common childhood chronic rheumatic disease and
causes much disability. We investigated the relation of serum 14-3-3 η (eta) protein in
oligoarticular JIA (OJIA) and; the disease activity and severity.
Methods: This study is a case control study including 14 JIA patients and 14 control
group. Patients were (6 males and 8 females).14-3-3η was measured for all patients and
control volunteers by enzyme-linked immunosorbent assay (ELISA) technique. ANA was
measured by indirect immunofluorescence (IIF) technique. Disease activity was assessed
by the Juvenile Arthritis Disease Activity Score27 (JADAS-27). Functional ability was
assessed by childhood health assessment questionnaire (CHAQ), and disease severity was
assessed by juvenile arthritis damage index (JADI). Radiological damage was assessed by
Results: Elevated 14-3-3 η levels were detected in 5/14 (35.7%) patients. Positivity for 14-
3-3 η was significantly related to disease activity, severity and ANA. Positivity for 14-3-3 η
had no significant correlation with CHAQ or Posnanski score.
Conclusion: Serum 14-3-3 η can be detected in oligoarticular JIA patients, and appears to
correlate with disease activity, severity and (ANA). But no correlation with CHAQ or