Online ISSN: 2515-8260

Author : Alok Pal Jain, Suraj Nanaware, Amit Nayak,

Development And Characterization Of Nasal In-Situ Gel Of Sumatriptan And Naproxen For Effctive Treatment Of Migraine Using 32 Factorial Designs

Suraj Nanaware, Amit Nayak, Alok Pal Jain

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 9201-9212

Over A Few Decades, Advances In The In-Situ Gel Technologies Have Spurred Development In May Medical And Biomedical Applications Including Controlled Drug Delivery. For Locally Acting Intra Nasal Drugs, An Extended Residence Time In The Nasal Cavity Is Desirable And Related To A Prolonged Effect. The Aim Of The Present Work Was To Design A Nasal Delivery System With Improved Mucoadhesive Properties That Could Provide Prolonged Retention Time For The Treatment Of The Allergic Rhinitis.  A 32 Factorial Design Was Used To Investigate The Effect Of The Amount Of Gellan Gum, Cmc And Tween 80 As Independent Variables. Gelling Time (Sec.), Viscosity (Cps) And Percentage Drug Content Were Taken As Dependent Variables. The Formulations Were Tested For Mucoadhesive Strength In-VitroDrug Release Study. The Study Shows That Administering Sumatriptan And Naproxen Using In-Situ Gel Is Feasible. As A Result, The Created In Situ Gel Formulation Could Be A Potential Carrier For Sumatriptan And Naproxen, Especially Given Its Ease Of Manufacture And Scale-Up.