Online ISSN: 2515-8260

Author : Azim, Baykulov


THE STATE OF FREE-RADICAL OXIDATION OF LIPIDS IN EXPERIMENTAL MYOCARDIAL INFARCTION IN RATS

Baykulov Azim; Djalilov Mustafo; Eshimov Dusmurat; Yusupova Saodat; Kim Oksana; Sovetov Kаrоkul

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 816-820

Lipid peroxidation products are capable of inhibiting the activity of enzymes of glycolysis and oxidative phosphorylation, inhibiting the synthesis of protein and nucleic acids, inhibiting many membrane-bound enzymes and thus exerting a pronounced damaging effect on cells and the body as a whole. It is of particular interest to study the intensity of lipid peroxidation in the body during myocardial infarction, which was the price of this study.

ANALYSIS OF THE SELECTION OF THE COVERING MATERIAL FOR THE TREATMENT OF THERMAL BURN OF THE SKIN

Baykulov Azim; Abdullayev Davlat; Narzikulov Rustam; Oripov Rustam; Yermanov Rustam; Mamirov Vasliddin; Islamov Nurali

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1785-1808

Background: Despite the vast experience of treating burns in surgery, a large number of victims become disabled; therefore they represent a serious medical and social problem.
Methods: The study included 120 white outbred male rats, which were simulated an experimental 3-degree topical burn and were divided into 4 groups according to the type of treatment substance. The burn was simulated by immersing the depilated skin area in boiling water. Studies of wound healing were carried out in three series, respectively, on the third, seventh and tenth days.
Results: We found that the local application of chitosan derivatives at an early stage leads to healing of the wound defect in rats in our experimental model. This was associated with a decrease in endogenous intoxication, lipoperoxidation, and internucleosomal degradation compared to the control group.
Conclusion: Thermal damage is accompanied by increased internucleosomal skin degradation. Compared with levomecol, chitosan derivatives more effectively reduce the degree of internucleosomal degradation, especially on the 10th day of the experiment.