Online ISSN: 2515-8260

Author : Attri, Harmohinder Kumar


Assessment of impact of Oral Contraceptives on Lipid Profile in Premenopausal Women

Harmohinder Kumar Attri; Tejinder Singh; Raj Kumar; Kuldeep Kumar; Arun Puri

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3023-3027

Background: World is facing the most serious problem that is population explosion. Contraception method is used worldwide for over birth control or unwanted pregnancies. Hence; the present study was undertaken for assessing the impact of oral contraceptives on lipid profile in Premenopausal Women.
Materials & methods: A total of 30 pre-menopausal subjects were enrolled. All the subjects belonged to the age group of 30 to 40 years. Only those subjects were included in the study group which has been using oral contraceptives for the last 3 months. Another set of 30 subjects with negative history of intake of oral contraceptives were taken as controls. Complete demographic and clinico details of all the patients were obtained. Blood samples of all the patients were obtained and were sent for analysis of lipid profile. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software.
Results: Mean serum cholesterol levels among the patients of the study group and the control group was 196.5 mg% and 181.4 mg% respectively. Mean serum triglyceride levels among the patients of the study group and the control group was 95.4 mg% and 82.6 mg% respectively. Mean serum high density lipoproteins levels among the patients of the study group and the control group was 41.6 mg% and 42.8 mg% respectively. Mean serum
cholesterol levels and serum triglyceride levels among the patients the study group was significantly higher in comparison to the patients of the control group.
Conclusion: Use of oral contraceptives significantly alters the lipid profile in premenopausal women.

Assessment of profile of patients with Pancytopenia

Harmohinder Kumar Attri; Arshia Bansal; Arun Puri; Raj Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3007-3014

Background: Pancytopenia is characterized by a decreased number of at least two blood cell
lines. The clinical features depend upon both of the underlying disease process as well as
relate to the blood cell lineages affected. Hence; the present study was undertaken for
assessing the profile of patients with pancytopenia.
Materials & methods: A total of 20 patients with pancytopenia were enrolled. Complete
demographic and clinical details of all the patients were recorded. Thorough history of all the
patients was obtained. Blood samples of all the patients were obtained. Diagnosis of
pancytopenia was established. Clinical profile of all the patients was recorded. All the results
were analysed by SPSS software version. Chi square test was used for assessment of level of
significance P value of less than 0 05 were taken as significant.
Results: Mean age of the patients was 40.3 years. 60 percent of the patients were males while
the remaining were females. Generalized weakness and pallor was seen in 100 percent of the
patients while fever and bleeding was seen in 60 percent and 15 percent of the patients.
Reticulocyte count was ≤ 0.5%, 0.6 to 1% and 1.1 to 2% in 25 percent, 50 percent and 25
percent of the patients respectively. Hypercellular bone marrow, Hypocellular bone marrow
and Normocellular bone marrow was seen in 80 percent, 15 percent and 5 percent of the
patients respectively. Megaloblastic anaemia was the cause of pancytopenia in 60 percent of
the patients while aplastic anaemia and sepsis was the cause in 15 percent and 10 percent of
the patients respectively
Conclusion: Bone marrow examinations, aspiration cytology or biopsy are important tool for
diagnosis of pancytopenia. Underlying cause and severity of disease determine the outcome
of pancytopenia.