Online ISSN: 2515-8260

Author : Abdulrazzaq, Ghayth M

Effect of Xanthine Oxidase Inhibition on Immunity Modulation in Human

Abdulla A Ahmad; Marwan M Merkhan; Ghayth M Abdulrazzaq

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1307-1316

Xanthine oxidase (XO) is a ubiquitous complex cytosolic molybdoflavoprotein which controls the rate limiting step of purine catabolism by converting xanthine to uric acid. It is known that optimum concentrations of uric acid (UA) and reactive oxygen species (ROS) are necessary for normal functioning of the body. Aim: This study is conducted to clarify the impact of xanthinoxidase (XO) inhibition on immunity function in human. Materials & Methods: Patients with renal stone were enrolled in this study. Patients took xanthine oxidase inhibitor (allopurinol) 100 mg/day for 6 months to reduce UA level, and the immune function is estimated by measuring some immunological parameters (IgG, IgA, complement C3 and C4). Blood samples were collected from patients before and after therapy. Autoanalyzer was used to measure the level of uric acid, IgG, IgA, complement C3 and C4. Results: Serum uric acid was significantly lowered after the treatment with allopurinol. Both IgG and IgA were elevated significantly due to allopurinol intake. However, complement C3 and C4 have not been changed after the same period of treatment. Conclusion: Long term inhibition of xanthine oxidase may affect the immunity by modulating immunological parameters in patients with renal stone.

Coronavirus (COVID-19): preventive measures and potential interventions

Marwan M Merkhan; Ghayth M Abdulrazzaq; Hiyam A Al-Taii

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1388-1399

Novel viral eruption originating in Wuhan city (Hubei, China) has spread internationally reaching all continents in an unexpectedly very short time, posing a great burden on global transportation, health, and economy. This mini-review article aimed at focusing on the available preventive measures and therapeutic interventions taking into account that there is a limited scientific resource of information and lack of specific established vaccination yet We searched Iraq Virtual Science Library (IVSL), PubMed, Cochrane Library MEDLINE, EMBASE, and the Chinese Biomedical Database (CBM), for the 3 target words ‘COVID-19, coronavirus, 2019-CoV’ and we included only articles in English in the study. The outcome of this study is important nationally and globally providing information about general measures and possible interventions relevant to public and health professionals. This review concludes that the nutritional status of the patient together with proper diagnosis should be the priority of the management plan provided that the loci is within the outbreak area and available flu vaccines should be used by unaffected health-care providers and children.