Author : Azizov, Shuhrat I.
Hereditary Polymorphism Of The Sodium-Uretic Peptides System And Long-Term Results Of Coronary Artery Stenting
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 3, Pages 3519-3534
The point of the study was to decide the impact of hereditary polymorphism on the impacts of endovascular revascularization in patients with coronary heart disease, angina pectoris FC III-IV.
The research included 158 patients with coronary heart disease with angina pectoris of FC III-IV pressure (ladies 34 -21.52%). Upon consideration within the ponder, all patients experienced: Echocardiography, TLC, genotyping of 6 genes of the system of natriuretic peptides, coronary angiography and stenting of the coronary courses. For follow-up examination, patients were welcomed after a year. The study included echocardiography, TLC, stress echocardiography.
Hereditary investigation permits foreseeing the drawn out impact of coronary supply route stenting: the overall danger of coronary illness movement (as stress-incited ischemia) in patients with minor alleles is 2.12 occasions higher than in patients with prevailing homozygotes for qualities of the natriuretic peptide system.
The current examination found that the presence of minor alleles of qualities of the arrangement of natriuretic peptides is related with a more prominent pervasiveness of atherosclerotic injuries of the coronary bed, the movement of underlying and useful rebuilding of the heart. What's more, the presence of minor alleles lessens the drawn out adequacy of coronary revascularization, both in the part of coronary atherosclerosis and in the part of the utilitarian condition of the myocardium (movement of LV dilatation and preservation of the sleeping myocardium).