Online ISSN: 2515-8260

Author : Aman, A Makbul

Expression Of Interleukin-6 Levels In Elderly Sarcopenia

Resliany Rachim; Agus Sudarso; Shanti Pricillia Makagiansar; Syakib Bakri; Haerani Rasyid; A Makbul Aman; Hasyim Kasim; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2837-2844

Background/Aim: Sarcopenia is a syndrome characterized by progressive loss of muscle mass and strength with a risk of adverse clinical outcomes such as physical disability, reduced quality of life, and death. Oxidative stress and inflammatory processes are known as factors that trigger sarcopenia by releasing the catabolic stimuli of IL-6. Based on this we study the dynamics of interleukin-6 (IL-6) in elderly sarcopenia in Wahidin Sudirohusodo Hospital Makassar.Method: This study was an analytic cross-sectional design conducted at the Geriatric Polyclinic of Wahidin Sudirohusodo Hospital, Makassar in March-June 2020. The assessed variables were degree of sarcopenia (probable sarcopenia, sarcopenia, dan severe sarcopenia) based on The European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria, age, sex, number of comorbids, and IL-6 levels examination. Statistical analysis was performed by descriptive statistical calculations and frequency distribution as well as the Independent-t statistical test, and Anova test. Results: Studied from 82 subjects (51 females, 62.2%) with the mean of 68.95 years of age. The prevalence of probable sarcopenia was 40.2%, sarcopenia 8.5%, severe sarcopenia 6.1%, and normal 45.1%. IL-6 levels were found to be significantly increased according to the severity of sarcopenia (normal, 52.81 ng/; probable sarcopenia, 67.47 ug/L; sarcopenia, 135.36 ng/L; and severe sarcopenia, 287.99 ng/L). Based on age, IL-6 levels increased significantly with age (60-74 years, 63.28 ng/L; 75 years, 139.35 ng/L). Based on the number of comorbids, IL-6 levels increased significantly according to the number of comorbids (1-3 comorbids, 52.86 ng/L; 4 comorbids (120.84 ng/L). Conclusion: In the elderly subject, IL-6 levels increases according to the severity of sarcopenia. IL-6 levels also increases with age, and the number of comorbids.

Profile of Vitamin D and Interleukin-8 in COPD Exacerbation

Riswan Idris; Muhammad Ilyas; Erwin Arief; Syakib Bakri; A Makbul Aman; Haerani Ra-syid; Hasyim Kasim; Andi Fachruddin Benyamin; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1484-1494

Background: To determine the profile of vitamin D and interleukin-8 (IL-8) in COPD exacerbation.
Method: This research is an analytical study with a cross-sectional approach conducted at the Wahidin Sudirohusodo Hospital Makassar from March-June 2020. Serum levels of vitamin D (25-hydroxyvitamin D) and IL-8 were measured using the ELISA method in 65 exacerbated COPD patients based on clinical examination, chest radiograph, & spirome-try. The exacerbation criteria were based on Anthonisen and divided into two groups ac-cording to the exacerbation frequency in the past year (frequent exacerbations was often ≥ 3 times/year, infrequent exacerbation < 3 times/year) and related to gender, age, nutrition-al status, smoking status based on the Brinkman index, and obstruction degree according to the Global Initiative for Obstructive Lung Disease (GOLD) 2019.
Results: This study consisted of 65 exacerbated COPD subjects (62 men, 95.4%), with age of ≥ 60 years 73.8%, frequent exacerbations of ≥ 3 times/year, 69.3%, vitamin D deficiency status of 76.9 %, and it was found to be significantly lower (15.1 ng/ml) at the frequent ex-acerbations of ≥ 3 times/year (P <0.01). The means of IL-8 levels were 187.48 +68.30 ng/L and found to be significantly higher (206.7 ng/L) in the frequent exacerbations ≥ 3 times/year (P <0.01). In all subgroups according to gender, age, nutritional status, smok-ing status, and obstruction degree, there was a tendency for the lowest vitamin D and higher IL-8 in the frequent exacerbations of ≥3times/year. Conclusion: Vitamin D levels were found to be the lowest and IL-8 was higher in COPD patients with frequent exacerbations of ≥ 3 times/year, compared to those with the infre-quent exacerbations of < 3 times/year.