Online ISSN: 2515-8260

Author : Badrany, Khalid, A. Al-


Synthesis of some New 4,6-dichloro-2-aminobenzothiazole compensators with expected biological

Enas,Jassim. Al- jubory; Khalid, A. Al- Badrany; Omar A. Kanoush

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1595-1606

was prepared from the reaction of compensated aniline with potassium thiocyanate in the presence of bromine. Unsaturated
Alpha-Beta (E2-6) compounds were obtained from the reaction of aromatizing aldehydes with para –hydroxyacetophenone in a
basal medium. The interaction of alpha-beta - unsaturated compounds with 4,6-dichloro-2-aminobenzothiazole gives
compounds (E7-11) 4-(1-(4,6-dichlorobenzothiazole-2-El amino) - 3-aryl) phenol. The bioavailability of compounds prepared
on two types of Gram-negative and Gram-positive bacteria was tested using a lower inhibitory concentration and compared
with standard antibiotics. The prepared compositions were validated using physical and spectral methods using FT-IR,H1-
NMR,C13NMR technology