The colour of a lesion is because of its nature and its histological substratum. Oral cavity lesions have been classified according to their colour in: white, red, white and red, bluish and/or purple, brown, grey and/or black lesions to ease its diagnosis. The interpretation of the lesions by its colour is the first step to diagnosis. Clinical diagnostic skills and good judgment forms the key to successful management of yellow lesions of the oral cavity.