Tooth loss is quite common worldwide. For treating a lost tooth, treatments such as dental implants (most common worldwide), fillings (made up of inert dental material), dentures, etc. These techniques can restore all the functions of a normal tooth. But using dental tissues and other dental related materials are still a mystery to the dental world. Pubmed research revealed 117 relevant articles. Out of which a total of ‘33’ systematic reviews and their original citations were included in this review. Tooth regeneration is a very complicated process and needs more depth study on this topic. From many of the researches that were reviewed in this article it was seen that there were many new methods developed but none were approved for applying in real life. Tooth regeneration is a vast topic and requires a lot of knowledge to be understood. This study can be used as reference for future research.