BACKGROUND: Data on potentially modifiable risk factors and clinical profile of severe malnutrition for infants under 6 months of age (U6M) are needed. This is vital to design and develop better future interventions. Our study aims at identifying these risk factors and clinical profile. MATERIAL AND METHODS: Prospective Observational study was undertaken on 88 infants U6M, who attended the Inpatient and OPD for a period of 1 year. Study was done to identify risk factors and clinical profile. RESULTS: Among 88 children enrolled in the study, most babies who developed Severe Malnutrition were term babies (86.4%) with birth weight 2-2.5 kg (43.2%). Majority (40%) were among 2-3 months of age. More (63.6%) were females. Approximately 56.8% were born to young mothers (21-23 years), uneducated and house wives. CONCLUSION: Risk factors like young maternal age, low level of education among mothers, low socio-economic status of family was contributary factors. But other factors like family size, birth order of infant, duration of breast feeding, feeding of top milk like cow or buffalo milk, mix feeding, mode of feeding, impact of NRC registration also have a significant impact on severe malnutrition in infants U6M. Further, Lack of exclusive breast feeding is also one of the perceived risk factors for severe malnutrition in infants u6m. Concerned health programs must include maternal education and knowledge about infant feeding practices as a major agenda.