Aim: The current examination was attempted to research the pharmacological screening of depressant action for hydroalcoholic extract of aloe vera on mice. Material and Methods: The hydroalcoholic concentrate of aloe vera were make the diverse measurements type of 150mg/kg and 300mg/kg given to mice (p.o) of test gathering Fluoxentine 20mg/kg given to mice (i.p) of standard gathering and controlled gatherings were directed refined water as vehicle (10ml/kg). The idleness time were recorded for six minutes in creature screening model of constrained swimming test and tail suspension test model. Results: In FST model of sadness, mean idleness time in seconds in Fluoxetine (20mg/kg) treated gathering was 94.00, 92.00 and 90.00 seconds on day first, seventh and fourteenth day. In Hydro alcoholic concentrate of Aloe Vera (150mg/kg) treated gathering was 88.00, 86.50 and 82.50 seconds on day first, seventh and fourteenth day, while in Hydro alcoholic concentrate of Aloe Vera (300mg/kg) treated gathering was 81.00, 73.00 and 69.90 seconds on day first, seventh and fourteenth day. In TST model of melancholy, mean fixed status time in seconds in Fluoxetine (20mg/kg) treated gathering was 100.015, 95.50 and 90.00 seconds on day first, seventh and fourteenth day. In Hydro alcoholic concentrate of Aloe Vera (150mg/kg) treated gathering was 96.885, 93.50 and 90.00 seconds on day first, seventh and fourteenth day, while in Hydro alcoholic concentrate of Aloe Vera (300mg/kg) treated gathering was 90.435, 86.00 and 80.00 seconds on day first, seventh and fourteenth day 14. Conclusion: The impact of Hydro alcoholic concentrate of Aloe Vera (150mg/kg and 300mg/kg) with standard medication Fluoxetine (20mg/kg) showed good upper consequences for mice (p< 0.0005). Better impacts were seen by utilizing this medication. So, the current examination recommends the better impact of Hydro alcoholic concentrate of Aloe Vera about the stimulant impact in correlation with Fluoxetine.