Background: Hypothyroidism is a endocrine disorder which results in neurological dysfunction. It also affects brain, peripheral nerves and muscular system. The study was undertaken to evaluate the sensory nerve conduction parameters in hypothyroidism. Materials and Methods: A present case control study was done in the patients of hypothyroidism to evaluate the sensory conduction.Fifty cases of Hypothyroidism with increased serum Thyroid Stimulating Hormone (TSH), and decreased serum FT4 and fifty normal subjects were included in the study. Sensory examination was done. Nerve Conduction Studies were carried out according to standardized protocols for bilateral median, ulnar, and sural sensory response. Nerve Conduction Velocity were recorded. The increased SDL and decreased SNCV in any nerve indicate sensory conduction impairment of that nerve. The recorded data was compiled and data analysis was done using SPSS Version 20.0 (SPSS Inc., Chicago, Illinois, USA). Results: In the present study while comparing the SNCV between the two groups, the SNCV of right median (43.65±8.12) was found to be significantly decreased in hypothyroid subjects as compared to the SNCV of right median (50.45±7.67) in the control subjects. The SNCV of left median (47.34±7.13) was found to be significantly decreased in hypothyroid subjects as compared to the SNCV of right median (49.56±6.56) in the control subjects. The SNCV of right ulnar (51.12±6.67) was found to be significantly decreased in hypothyroid subjects as compared to the SNCV of right ulnar(53.67±8.11) in the control subjects. The SNCV of left ulnar (52.54±6.78) was found to be significantly decreased in hypothyroid subjects as compared to the SNCV of left ulnar(55.56±5.34) in the control subjects. The SNCV of right sural (42.34±5.76) was found to be significantly increased in hypothyroid subjects as compared to the SNCV of right sural (41.45±6.42) in the control subjects. The SNCV of left sural (41.23±4.53) was found to be significantly decreased in hypothyroid subjects as compared to the SNCV of left sural (41.34±7.23) in the control subjects. Conclusion: The present study concluded that SNCV between the two groups was found to be significantly decreased in hypothyroid subjects as compared to the SNCV in the control subjects.