Aim: To determine the relationship between biochemical indicators and the severity of COVID-19. Methods: Blood samples were obtained by competent doctors and nurses in accordance with ICMR guidelines. The samples were then forwarded to the central biochemistry laboratory for additional analysis. The Access-2 completely automated chemical analyzer was used to test ferritin, quantitative CRP, and IL-6, while the AU 480 analyzer was used to assess LDH. Results: We included 200 confirmed covid-19 patients in our trial. All of the patients were above the age of 18. The prevalence of HTN, diabetes, CKD, COPD, and Cardiac Disease in the study patients was 40%, 32%, and 15%, respectively. 20 and 30 percent, respectively. In the current research, the mean values of IL-6, ferritin, CRP, and LDH were shown to be higher in covid patients, with the rise being greater in patients on intubation. The mean and standard deviation of biochemical parameters in non-ICU, ICU, and intubation patients. Conclusion: Serum CRP, LDH, IL-6, and ferritin levels that are increased may be employed as laboratory indicators for a bad prognosis in COVID-19.