Aim: The purpose of this research is to assess the efficacy of bupivacaine against levobupivacaine in supraclavicular brachial plexus block. Methods: The research comprised 100 patients between the ages of 20 and 55 who had upper limb orthopaedic and soft tissue lesions and weighed more than 61 kilos and had ASA grades I and II. The first group received 1 ml (100g) dexmedetomidine mixed with 39 ml of 0.5 percentLevobupivacaine. As an anaesthetic agent, category II received 1 ml of 0.9 percent normal saline and 39 ml of 0.5 percentLevobupivacaine. The heart rate, respiration rate, SBP, DBP, pulse rate, and oxygen saturation were all monitored and recorded as soon as the patient entered the OT. In the previously secured intravenous line, ringer lactate was begun. The supraclavicular technique was used to provide brachial plexus block.