Aim: to study clinical and pathological factors of gastric cancer in Ranchi region, India. Material and methods: This study was carried out in the Department of General Surgery, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, for 3 years (1 july 2012,30 june 2015) Total 650 patients were included in this study. Results: Of these 650 patients, 460 (70.77%) male and 190 (29.23%)female, 395 (60.77%) underwent distal gastrectomy, 30 (4.62%) proximal gastrectomy via abdomen and 157 (24.15%) via thorax, and 68 (10.46%) underwent total gastrectomy. Distal and total gastrectomy had more numbers of clearances of lymph nodes than the other operational approaches. The postoperative complications occurred in 55 patients 55/600, 8.46%,including gastric retention in 14(14/55, 25.45%), anastomotic leakage in 10(10/55,18.18%), infection of incision in 9(9/55, 16.36%), disruption of wound in 5(5/55, 9.09%), and thoracic cavity effusion in 5(5/55,9.09%). The complication was most common in proximal gastrectomy via abdomen (12/55,21.81%patients).The overall mortality was 0.77% (5/650). The diameter of the neoplasm was positively correlated with the depth of infiltration and lymphatic metastasis rate while hemoglobin was the opposite. 95(14.61%) of 650were early gastric carcinoma (EGC) with metastasis of lymph nodes in 14 patients (14/95, 14.74%). The frequency of positive lymph nodes in these patients was 4%-5% less than in advanced gastric cancer. In linear regression analysis, age and diameter of the tumor were negatively correlated with the preoperative hemoglobin (P<0.001). Conclusion: This retrospective study has shown that clinico-pathological characters in gastric cancer varied with sex, location, and diameter of the tumor.