Abstract: The aim of this study was to assess the state of indicators of the hemostasis system of blood and saliva in patients with CGP concomitant CHF. 109 people aged 40 to 60 years, with signs of chronic generalized periodontitis (CGP) concomitant CHF were examined. In accordance with the objectives of the study, 3 groups were formed: Group I - 50 patients (39 men and 11 women) with chronic generalized periodontitis on the background of AH and IHD, Group II - 34 patients (22 men and 12 women) with CGP on the background of AH and IHD combined adentia, group III - 25 patients (15 men and 10 women) with periodontal pathology (CGP), without diseases of the cardiovascular system (CVS). Revealed hyperhomocysteinemia and an increase in the procoagulant activity of saliva and blood, which is a consequence of not only CGP, but also atherosclerotic process, in which a thrombogenic threat is created due to the involvement of endothelial cells of the oral mucosa in this process.