Abstract: The present comparative study was done between normal and patients with diabetes and kidney disease in Diyala city in Iraq. The studied ages were ranged between 40 and more than 69. Serum samples were collected from hospitals in Diyala province. The result revealed that the serum sugar values behave in different manner than that of urine and creatinine values. The result showed that male patients percentage (50.0%) was less than male controls percentage (56.0%), while female patients percentage (50.0%) was more than female controls percentage (44.0%) With no significant differences (P> 0.05) among groups according to gender. Blood sugar, blood urea, and serum creatinine were higher in males compared to females. in males blood sugar was higher According to age, the highest age periods in patients was (50-59 year) and in control was (40-49 year), while the lowest age period in patients was (30-39 year ) and in control was (>69 year ) with high significant different between groups according to age periods. The mean value of serum sugar was high in the patients than control group with high significant differences between groups. The mean values of serum urea were high in patients from the control group with significant differences between groups. Besides, the mean values were significantly higher in Serum Creatinine in patients than controls. the mean value of Blood Sugar was higher in male patients than female with non-significant differences (P>0.05) among patients. So, the mean value of Blood Urea parameters was high in male patients than female with non-significant differences (P>0.05) among patients. Besides, the mean values of Serum Creatinine were higher in males patients than females with non-significant differences (P>0.05) between patients. Blood sugar did not settled, it goes up and down between the age forty to the age over 69.The least mean values of Blood Sugar were between (50-59) year and the highest values were between (60-69) year with non-significant differences among patients age. On the other hand, the least mean values of Blood Urea were between (40-49) year and the highest values were more than 60 years with non-significant differences among patients age. Besides, the least mean values of blood urea and Serum Creatinine lied between (40-49) years. With age, these values were elevated.