Nurse performance is very important for a hospital. Nurse performance at Medan Mitra Sejati General Hospital is still low. The low performance of nurses in Mitra Sejati Hospital is related to the self-efficacy experienced by nurses. This study aimed to analyze the influence of self-efficacy on nurse performance. The study was analytic survey research with a cross-sectional design. The population was all nurses who served in Mitra Sejati Hospital Medan with a total of 168 people and a sample of 138 people. Data collected by primary and secondary data and analyzed by statistical tests of Multiple Logistic Regression with a confidence level of 95%. The results showed that the magnitude/level (p = 0.011), strength (p = 0.001) and generality/generalization (p = 0.017) affected the nurses performance in Mitra Sejati Hospital and which most influenced the nurse performance Mitra Sejati hospital was a strength dimension (OR=14,457). It is recommended for nursing services the need to provide an understanding to each nurse about the importance of self-efficacy experienced so that nursing services can be carried out to the maximum, superiors should provide an assessment of the performance of implementing nurses continuously and continuously, for the nursing nurses to be able to practice nursing by managing and coordinating nursing care by integrating the needs of clients, families, staff and policymakers and the participation of nurses in hospital committees can also be an effective solution in an approach to improve self-efficacy, one of which measures the self-efficacy experienced and nurses can reveal situations that can lead to self-efficacy.