Abstract: Dengue Hemorrhagic Fever (DHF) risks causing death when the sufferer experiences shock due to bleeding. Until now, there is no specific drug to cure DHF. This study was aimed to determine the effect of interpersonal communication on improving the prevention of Dengue Fever (DHF). The type of research used is Quasi-experiment with nonrandomized pretest-posttest control group design. Samples were taken by simple random sampling of 78 respondents from a population of 1,791 households each of 39 respondents in the intervention group and 39 in the control group. Data collection uses questionnaires and interviews in the working area of the Baubau City Meo-Meo Community Health Center. Data were analyzed using the Wilcoxon and Man Whitney tests. The results showed the percentage of respondents characteristics in this study the most age groups were 28-38 years 39.74%, female sex 79.48%, married 92.31%, high school education 56.41%. The mean score increased knowledge (13.21 to 17.49), AND attitudes (33.38 to 38.92) about DHF before and after interpersonal communication. The mean score increased knowledge (12.69 to 16.49), and attitudes (33.33 to 37.46) about DHF before and after counseling. While the comparison of the intervention group was significant from the control group with (p <0.05) namely knowledge (p = 0,000), and attitude (p = 0.021) about DHF. Interpersonal communication is more influential than counseling and the need for monitoring and evaluating the implementation of interpersonal communication on an ongoing basis.