Chronic obstructive pulmonary disease is a disease condition characterized by a progressive and not reversible airflow previously associated with an abnormal inflammatory response in the lungs to harmful substances. This can overcome the nursing problem in the form of gas transfer problems. As a nurse, the thing that can be done is to do an independent intervention consisting of orthopneic position and to try to improve breathing status based on the results of the classification of nursing results, namely breathing frequency, oxygen saturation, and chest wall retraction. The study aimed to investigate the combination of orthopneic position and breathing lips on the respiratory status of COPD patients. The study was quantitative with the quasi-experimental approach. Seventy-two were sample divide into two groups, namely, 36 control and 36 intervention group using purposive sampling. Data were analyzed using Wilcoxon signed-rank test and Mann Whitney Test. The results found significant differences between before and after the intervention with values for respiratory frequency 0,001, oxygen saturation 0,001, and chest wall retraction 0,005, then found differences between the control group and comparison of respiratory frequencies and oxygen saturation <0.005. The Intervention of combination orthopneic position and pursedlips breathing can improve the respiratory status of COPD patients, namely: respiratory frequency, oxygen saturation, and chest wall retraction.