Abstract: TBI is a complex pathophysiological process that includes primary and secondary brain damage that affects the structure and function of the nervous system. The incidence of TBI is 3 times higher than the population growth and the cost of treatment is more than 33 billion euros per year. Recently, there has been a growing interest in hypertonic saline solutions, which act in the same way, exerting an osmotic effect, increasing the movement of water from the tissues into the circulatory system. The present study was to study the efficacy and safety of using 7% NaCl in the treatment of intracranial hypertension in patients with isolated traumatic brain injury in the adult population. This group consisted of 35 patients with isolated traumatic brain injury at the age of 21-80 years (42.6 ± 13.2 years).