Background: In individuals with end-stage renal disease (ESRD), those on hemodialysis, and those with stage 3–5 chronic kidney disease, reduced kidney function is linked to low levels of high-density lipoprotein cholesterol (HDL-C) (CKD). However, there is a scarcity of epidemiological data on the link between HDL-C levels and renal function in the general population with roughly normal kidney function, and the results are conflicting. The goal of this study was to see if there was a link between HDL-C levels and estimated glomerular filtration rate (eGFR) in an Indian community