Taste sensation plays a major role in detection and ingestion of food to face the nutritional requirements in health and disease. Alteration in taste perception causes malnutrition which is one of the usual causes of morbidity and mortality in cancer patients. This review reveals the mechanism of taste perception and their alteration in cancer, it also reveals the role of radio- and chemotherapy in the modulation of taste sensation. Preventive measures, dietary supplements and pharmacotherapy to improve the patient’s status in advanced cancer stage are also explained in this review.