Abstract: The present prospective study has been carried out in the Department of General Surgery, KIMS Karad, out of 200 cases that had undergone other surgical procedures. The rate of infection of the surgical site and the frequency of various pathogens caused surgical site infection in general surgery units with their antibiotic resistance patterns. Aim of the study is to prevent or reduce the incidence of surgical site infection in clean, hygienic and contaminated cases.Surgical site infection (SSI) is both the most frequently studied healthcare-associated infection and the most common healthcare-associated infection. Incidence of General Surgical Site Infection is 5.5%. Older age group is commonly involved. Risk factors like anemia, diabetes mellitus, hypoproteinemia, and hypertension are associated with increased Surgical Site Infection rate. Contaminated cases had more SSI rate (23.33%) as compared to clean- contaminated cases (4.82%). Most of the bacterial isolates were multidrug resistant.