Background: Alcohol dependence syndrome is a chronic disorder resulting indisturbances of various cognitive function areas. Neuro-anatomical and functional changes of the brain most often affect the prefrontal cortex of the brain and the hippocampus. Methods: A study was conducted for a period of Two year, Department of psychiatry GMC, Bettiah. A total of 30 cases diagnosed with ADS admitted as psychiatry inpatients and 30 healthy controls wereincluded for the study after taking written informed consent. These patients were evaluated using Mini International Neuropsychiatric Interview (MINI-6), Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised (CIWA-Ar), Severity of Alcohol Dependence Questionnaire (SADQ), Trail making Test-A and B (TMT-A andB), Digit Span Test(DST), Word list, Stroop test(STR), Tower of Hanoi (TOH). Clinical details were noted during the course of interview.