Background: Human immunodeficiency virus (HIV) a lentivirus that acquired immuno deficiency syndrome (AIDS) in which there is progressive failure of the immune system with life threatening opportunistic infections and cancers. So there is a need to identify and establish relationship between serum albumin level with disease severity in HIV/AIDS patients. Methods: This is cross sectional study was conducted on 81 HIV/AIDS patients presenting to and registered ART center at Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, during the period from September 2020 to June 2021. A detailed history, clinical examination and laboratory investigations was done. Results: Our study the mean serum albumin level was 3.11 + 0.50. There was a significant correlation between serum albumin level with CD4 + counts was 0.627. Conclusion: Study indicating that albumin could be used as a supplementary marker for immunosuppression in HIV/AIDS patients.