Chronic Kidney disease (CKD) is characterized by change in kidney structure and function with different clinical manifestations, like its cause, severity and the rate of progression. Initial stages of CKD are often not symptomatic and may be reversible, which are detected during the evaluation of other comorbidities. This study was taken up to highlight the clinical presentation, etiology & complications in patients with CKD undergoing dialysis at tertiary care hospital in south Gujarat. The study was conducted among indoor patients diagnosed as chronic kidney disease to our tertiary care hospital & OPD Patients. Global quality of life scale was used for assessing quality of life. For renal size, renal length was considered from radiological studies. Blood investigations include complete blood count (CBC), Liver function test (LFT), Renal function test (RFT), calcium, phosphate, uric acid, thyroid profile, urine routine, coagulation profile, vitamin B12 & D3, Amylase, Ferritin, PTH, Mg, HbA1c, arterial blood gas (ABG), HIV, HBsAg, HCV. Radiological investigations include Chest Xray, Ultrasonography. Data will be entered in MS EXCEL spread sheet. Descriptive statistic applied as frequency and percentage. Most common cause observed foe CKD in this study was diabetes followed by hypertension. Upon identifying the risk factors in the general population, regular clinical and biochemical screening amongst them can help to halt or delay the reversible causes or process leading to the development of end-stage renal disease (ESRD). This will eventually decrease the mortality and morbidity in the general population having the risk factors for ESRD.