Introduction: - Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. In patients with Type 2 diabetes, low grade inflammation is reflected by increased plasma levels of several biomarkers such as C-reactive protein (CRP). Alkaline phosphatase (ALP) is a generally accepted clinical marker of hepatic or bone disease. It had been showed that elevated ALP acted as a prognostic indicator of decreased survival in diabetic patients with acute myocardial infarction (MI), possibly in association with decreased renal function in these patients. Materials and methods: This study was conducted in the Department of Biochemistry at Tertiary Care Teaching Hospital over a period of 6 months. A 5 ml of venous blood was drawn from each volunteer using a disposable vacutainer system in fasting condition. Post prandial (2 hour) sample collected in fluoride vacutainer for PP2BS estimation. Analysis of sample Fasting and post prandial (2 hour) blood sugar (FBS & PP2BS) estimated by glucose oxidase-peroxidase (GOD-POD) enzymatic end point method. Glycated hemoglobin (HbA1c) concentration was measured by High Performance Liquid Chromatography (HPLC) method. Serum ALP activity was determined by carboxy substrate kinetic method. Serum hsCRP level is measured by immunoturbidimetric method.