Abstract: The cancer survival journey starts for the person at the time of diagnosis and lasts until the end of life, with adverse effects on normal activities. Breast cancer mortality is strongly associated with poor sleep. Fatigation and decreased appetite are the hallmarks of cachexia in terminally ill patients. Inadequate medication adherence may cause alterations in risk-benefit ratios. Aim: To assess the sleep quality , fatigue, and medication adherence among breast cancer survivors and to find their association with the selected demographic variables. Methods: This was a descriptive cross-sectional analysis involving 60 samples of OPD medical oncology using a convenient sampling technique and the study duration was one week. Pittsburgh sleep quality index scale, Perform questionnaire, Medication adherence rating scale were used to assess the patients. RESULTS: The study concluded that 61.67% of the cancer survivors were disordered sleepers, 45.00% of the cancer survivors were having low fatigue score and 71.67% of the breast cancer survivors were having good medication adherence score. There was a strong positive equal correlation between the Sleep Quality Index score and the Fatigue score, which indicates that the quality of sleep raises the fatigue score. CONCLUSION: Clients suffering with breast cancer should be assessed for sleep quality, which directly helps to reduce the fatigue level. Evidence-based practice interventions like Exercises, cognitive behavior therapy, yoga, and aerobic exercises could help the patient to have adequate sleep.