Background: Red cell distribution width (RDW) to platelet ratio (RPR) is a prognosticator in acute pancreatitis and myocardial infarction; however, the prognostic values of RDW and RPR in breast cancer have not been studied. This retrospective analysis of 50 breast cancer patients investigated the association between RDW and RPR and clinicopathological characteristics and prognosis, compared to platelet distribution width to platelet count ratio (PDW/P) which is a known independent prognostic factor in patients with breast cancer. Aims and Objective: Our study aimed to know significance of elevated RPR in breast cancer, to correlate the RPR with the clinicopathological characteristics of breast cancer (tumor grade, lymphatic spread, over expression of hormonal receptors and HER2 protein).