Background:Diabetes mellitus has become a global pandemic and is estimated that it will be the leading cause of death as a non communicable disease by 2030.Diabetic nephropathy is a major long-term complication of diabetes mellitus (DM). Type 2 DM is frequently associated with an underlying low grade inflammatory mechanism , but less information is available on the relationship explaining the low-grade inflammation process and development of diabetic nephropathy (DN). The aim of this study is to determine the serum level of high sensitivity C-reactive protein (hsCRP) ,an acute phase reactant and Serum Total Sialic acid levels, a marker of excessive glycation in unregulated glycemic control in Diabetes mellitus patients leading to the complication of diabetic nephropathy .And to compare with the normal subjects and also to study the association between serum hsCRP levels and Serum Total Sialic acid levels.