Background: To assess serum total IgE levels in smokers, non- smokers and ex- smokers and its relation to lung function. Materials and Methods: One hundred twenty subjects of either gender were divided into three groups. Group I comprised of smokers, group II non- smokers and group III exsmokers. Weight and height was recorded followed by BMI. Symptoms and signs of cough, wheezing, dyspnoea were recorded. Alcohol history was also recorded. 5 ml of venous blood was taken for assessment of haemoglobin, ESR and absolute haemoglobin count. IgE level was assessed