Background: Infertility is an issue of global proportions, affecting 8-12% of couples globally on average. Latest studies have shown that the prevalence of oligozoospermia is exceedingly high inthe metropolis as well as in smaller cities in India. Infertility is characterized as the failure tobecome pregnant after 1 year of unprotected coitus. Male infertility is marginally less complicated than female infertility, but can account for 30-40 per cent of infertility. Oligozoospermia is one of the key factors in male infertility and is characterized as a subnormal concentration of sperm inthe penile ejaculate, i.e. less than 20 million per ml. The different drugs are mentioned to encourage fertility, and may be used to treat certain types of cases. Since the condition is stillunresolved and there is no full cure available. Acharya Charaka has identified numerous drugs thatare helpful in the treatment of Alpa, dushta retas that function directly on the properties of Shukra janana (spermatogenesis) and shukra shodhana. One of them is Apatyakar Ghrut. Go-ghrut isstrongest of all the Jangam snehas because it has a special capacity to adopt, i.e. SamsakarysaAnuvartanam, and this is Vrushya. In this research, an attempt was made to investigate the role ofApatyakar Ghrut in the infertile male in which oligozoospermia is the cause of infertility. ApatyakarGhrut is a poly herbal formulation stated to be useful for enhancing fertility. Aim: The purpose of this study was to determine the effectiveness of two months of oral administration of Apatyakar Ghrut. Materials and Methods: 30 eligible male participants between the ages of 21 and 50 years of age, with sperm count <20 million/ml, received Apatykar Ghrut at a dosage of 10ml orally twice daily before food containing lukewarm water as Anupana for a span of two months. Results: Apatykar Ghrut given an increase of 58.93% in overall sperm count, a 45.61% increase in sperm motility, a 14.45% increase in semen volume, a pH of 0.45% and a 14.51% decrease in liquefaction time. Conclusion: Administration of Apatykar Ghrut provided statistically significant improvementin desire, ejaculation, erection, orgasm, performance anxiety, sperm count, sperm motility, liquefaction period, volume of semen parameters relevant to male infertility, like oligozoospermia.