Background: How stress impacts the immune system of the human being is one of the questions that has been answered through many conducted researches. The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. Among recent examples presented nationally and internationally how immune system function properly to preventing the Coronavirus (COVID19) which appear at the end of 2019 and the beginning of 2020. Aim: The purpose of this review was to collect and corroborate updated information and trials related to the various effect of COVID19 on the immune system and how stress, loneliness, and lack of sleep can all weaken your immune system, making people more vulnerable to diseases such as COVID-19. Methods: To compile this review various journals, books, electronic databases, and other resources were used using keywords of immune system, Covid19, stress, and pandemics. The intent behind this review is to provide readers with an in-depth and updated knowledge about this pandemic virus to help resources available for utilization by families and communities. It is also directed towards identifying critical issues about decreasing the vulnerability to infection by improving our immune system, decreasing sources of stressors, and getting enough sleep. Conclusion: Covid-19 has been a wakeup call to us all. It made us realize how important having a strong immunity is. Therefore, people should give themselves a good fighting chance and make changes to their diet and lifestyle today. However, achieving this is not impossible since all agencies and scientists from everywhere are spending time, effort, and money to improve the understanding of the chronological features of CoV‐ induced inflammatory response concerning the creation of effective vaccine and therapeutic interventions.