Background:To evaluate the association of the demographic, clinical sign and symptoms and laboratory biomarkers in predicting the mortality in COVID-19 infected patients. Materials and Methods: This was a single centre retrospective observational study carried out in atertiary care centre of a tribal region of central India, which was a referral centre for COVID-19.Parameters taken into account were physiological parameters,symptoms at admission,radiographic findings and laboratory findings. Results: Out of 103 deaths included in this study 76 were male and 37 females (2:1). Mean age of the deceased were 54.90 years (18-90 years). The most common symptom on admission was breathlessness in 92 patients (89.32%). Abdominal symptoms like diarrhoea and vomiting were associated in 7.7 % of the deceased patients only.Most of the patients who died were older patients having age 60 years and above (65.04 %). Most of the patients who died had Spo2 less than 90 % on admission (85.43 %).Lymphopenia (92.23 %) was the most commonly observed finding on blood investigations done in deceased patients followed by increased CRP level (78.64 %). Comorbidities were present in 77 patients out of 103 patients (74.75%) included in this study. Diabetes and hypertension were being the most common comorbidities associated in these patients.Death was not commonly observed in patients with COVID 19 associated with respiratory diseases.