Abstract: Problem- Based Learning strategy (PBL) is one of the innovative teaching strategies that are used in undergraduate nursing education to help students learn how to apply knowledge effectively in a variety of clinical situations. PBL is considered as a convenient teaching and learning method for obstetric and gynecological nursing students. It also relates to its clinical practice to deal with and solve women’s problems. Purpose: This study aimed to explore nursing students’ perspectives about problem-based learning strategy used in Obstetric and Gynecological Nursing course. Design: descriptive exploratory research design was used in this study. Setting: This study was conducted at two scientific nursing departments at the Faculty of Nursing, Alexandria University namely, Obstetric and Gynecological Nursing Department and Pediatric Nursing Department. Subjects: The total number of students was 495 students. Tools: One tool was used for data collection: Nursing Students' Problem-Based Learning Strategy Perspective Questionnaire. Results: this study revealed that nearly more than three quarters of the students have a positive perspective toward PBL strategy. Conclusion: problem-based learning strategy is a valuable teaching method helped in achieving students' satisfaction regarding improving their learning skills. Recommendation: Problem-based learning strategy should be considered as a significant teaching method to be applied in different courses at the Faculty of Nursing. Moreover, Training workshops should be conducted to all nursing educators to enhance their abilities and competencies in the use of PBL strategy.