Aim: To analyze the clinicopathological and immunohistochemical features of primary central nervous system lymphoma (PCNSL) cases occurring in Indian patients and also study the utility of the crush smear preparation in intraoperative diagnosis. Material & Methods: 40 cases of PCNSL diagnosed in the Department of Histopathology, were included in this study. Haematoxylin and Eosin (H and E) stained slides and immunohistochemistry slides (which included a minimum of Leucocyte common antigen (LCA), CD20 and CD79aof all these cases were retrieved.