Generic systemic disability questions the success rate of the complete denture. Systemic factors are main determinants for prognosis of denture. Most complete denture age groups have contributing health causes.Most individuals in the entire denture age group are likely to have health conditions leading to denture difficulties. The general health status of the patient, host resistance and the systemic factors are the main determinants of the denture 's prognosis. A total of 372 patients were taken and analysed for systemic diseases in complete denture wearers.The study was done under university setting.The results were analysed using SPSS software version 20 by IBM. The result observed is that the prevalence of systemic disease is less in completely edentulous patients.From the present study it was observed that the presence of systemic disease completely edentulous patients is 38..17%.Additional care should be maintained while treating those patients.