Abstract :Office workers are known to be prone to work related musculoskeletal disorder but its prevalence among office workers in Egypt has not been reported. Purpose of study wasto study the prevalence of work related musculoskeletal disorders and to investigate relationship between physical risk factors and musculoskeletal disorders among Egyptian office workers in the previous 12 month. 400 office workers, volunteers with ethical approval and informed consent as a random sample were recruited from some general hospitals to assess musculoskeletal disorder due to work in the last 12 months. The participants were asked to answer Nordic musculoskeletal questionnaire. Reported 12 months prevalence of work related musculoskeletal disorders among Egyptian office workers, thelower back pain disorders with a percentage of 79% was the most commonly affected part. Elbow pain with percentage 19%was the least commonly affected part. Working prolonged periods in the same posture and sitting for long period weresignificantly related to lower back and neck pain. In Conclusion, The coping strategies and work factors of work related musculoskeletal disorders among Egyptian office workers are mostly similar to those of their counterparts elsewhere. The prevalence of work related musculoskeletal disorders among office workers in Egypt is higher than most values reported for their counterparts in other countries.