To address the shortcomings of natural ceramides, pseudo ceramides (PO3C, 6C, and 9C) were synthesised and used to build pseudo ceramide liposomes. When the PO9C:PC content was 2:1, the liposomes prepared with PO9C were 30 the smallest in size, with a particle size of 130 nm. Furthermore, the stability was higher than that of standard ceramide liposomes (CLs). Finally, a PC:ceramide ratio of 2:1 was chosen to carry baicalein because it optimized the particle size and stability of the liposome (BAI). The common CLs had an entrapment efficiency of 78.40 percent, whereas the pseudo-CLs had an entrapment efficiency of more than 80 percent. Notably, liposomes containing 9CL had the highest entrapment efficiency. TEM was used to confirm the morphology of BAI35-loaded pseudo-CLs. The concentrations of BAI loaded in ordinary CLs present in the stratum corneum, epidermis, and dermis, as well as transdermal permeation, were, respectively, and 4g/cm3. Concentrations of the pseudo-CLs, BAI-9CL were very similar. Finally, it is proposed that pseudo-CLs containing BAI (BAI-9CLs) are as effective as regular CLs in delivering the drug to the skin, but have the added benefit of being more stable.