Background: The objectives is to Screening of all the antenatal pregnant women for thyroid dysfunction, To study the maternal and fetal noutcome in pregnancy thyroid dysfunction, To provide adequate treatment and there by reduce adverse outcome, Follow up of cases six weeks post partum. Materials and Methods: Prospective, observational study. 110 patients were included. The study was conducted at Department of Obstetrics and Gynecology (OBG), Modern Govt MaternityHopsital, Petlaburz attached to Osmania Medical College, Hyderabad, Telangana, India during the period from 1st December 2019 to 30th June 2021.Mothers attending for ante-natal check-up and having either a detected or documented thyroid dysfunction. An Institutional Ethics Committee approval was obtained. Written informed consent was obtained from all the study participants. The mothers during their first visit were included for detailed history, clinical examination and blood investigations as follows