Since pain has been reported to occur in 25%–40% of patients treated for endodontics procedure, it is a major concern for dentists and their patients. Hence in dentistry, nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to treat pain and swelling. The most frequently used of these medications are ibuprofen and paracetamol. They work by inhibiting the enzyme cyclooxygenase, which then prevents the production of prostaglandins. All of these medications exhibit a comparable mode of action, which causes them to have comparable side effects. The present article reviews the knowledge currently available on NSAIDs with a focus on dental practice-related elements.